05 October 2015

Three scientists who discovered drugs against malaria and other parasites are awarded Nobel prize for medicine

  • William Campbell, Satoshi Omura and Tu Youyou share top honour
  • Scientists found new way of tackling infections caused by roundworm
  • Professor Youyou created new Malaria drug saving 100,000 lives a year
Three scientists have won the Nobel Prize in medicine for discovering drugs against malaria and other parasitic diseases that affect hundreds of millions of people every year.
Nobel judges in Stockholm, Sweden, awarded the prestigious prize to Irish-born William Campbell, Satoshi Omura, of Japan, and Tu Youyou - the first-ever Chinese medicine laureate.
Professors Campbell and Ōmura found a new way of tackling infections caused by roundworm parasites. 
The worms affect a third of the world's population and cause illnesses, including River Blindness and Lymphatic Filariasis. 
William C. Campbell, a parasitologist, poses near a collection of microscopes shortly after learning that he was a co-winner of the Nobel Prize for Medicine, at his home in Massachusetts
William C. Campbell, a parasitologist, poses near a collection of microscopes shortly after learning that he was a co-winner of the Nobel Prize for Medicine, at his home in Massachusetts
Professor Tu shares the prize for her discovery of a therapy against malaria, which has been found to significantly reduce deaths from the disease.
The Nobel committee said the scientists' work had changed the lives of the hundreds of millions of people affected by these diseases. 
'The two discoveries have provided humankind with powerful new means to combat these debilitating diseases that affect hundreds of millions of people annually,' the committee said. 
'The consequences in terms of improved human health and reduced suffering are immensurable.'
River blindness is an eye and skin disease that ultimately leads to blindness. About 90 per cent of the disease occurs in Africa, according to the World Health Organisation.
Lymphatic filariasis can lead to swelling of the limbs and genitals, called elephantiasis, and it is primarily a threat in Africa and Asia. 
The WHO says 120 million people are infected with the disease, with about 40 million disfigured and incapacitated.
Mr Campbell is a research fellow emeritus at Drew University in Madison, New Jersey. 
Mr Omura, 80, is a professor emeritus at Kitasato University in Japan and is from the central prefecture of Yamanashi. 
Kitasato University Professor Emeritus Satoshi Omura arrives for a press conference at the university in Tokyo. He has become the first-ever Chinese medicine laureate for discovering drugs against malaria
Kitasato University Professor Emeritus Satoshi Omura arrives for a press conference at the university in Tokyo. He has become the first-ever Chinese medicine laureate for discovering drugs against malaria
Pharmacologist Tu Youyou, pictured at an award ceremony in Beijing, in 2011,  jointly won the 2015 Nobel prize for medicine or physiology for her work against parasitic diseases
Pharmacologist Tu Youyou, pictured at an award ceremony in Beijing, in 2011,  jointly won the 2015 Nobel prize for medicine or physiology for her work against parasitic diseases
Ms Tu, 84, is chief professor at the China Academy of Traditional Chinese Medicine. 
The last time a Chinese citizen won a Nobel Prize was in 2012, when Mo Yan got the literature award. But China has been yearning for a Nobel Prize in science. This was the first Nobel Prize given to a Chinese scientist for work carried out within China.
The medicine award was the first Nobel Prize to be announced with the winners of the physics, chemistry and peace prizes set to be announced later this week.  
The winners will share £633,000 prize money, with one half going to Mr Campbell and Omura, and the other to Ms Tu.
Each winner will also get a diploma and a gold medal at the annual award ceremony on December 10, the anniversary of the death of prize founder Alfred Nobel.
Last year's medicine award went to three scientists who discovered the brain's inner navigation system.
The Nobel committee (pictured) said the work of the scientists, who are picture above) had changed the lives of the hundreds of millions of people affected by these diseases
The Nobel committee (pictured) said the work of the scientists, who are picture above) had changed the lives of the hundreds of millions of people affected by these diseases

25 September 2015

SWEDISH OTOVENT :(ABIGO MEDICAL AB) Using principles POLIZER AND VALSALVA

The Otovent® method is a clinically proven first-line treatment option to help avoid the surgical insertion of a tube into the eardrum. It is a non surgical, drug free treatment for glue ear, and has been recommended by ENT specialists for the last 20 years.
The child inflates a small balloon using their nose, and at the same time equalizes the pressure and relieves the symptoms in the middle ear. Blowing up the balloon helps to open up the Eustachian tube, making it easier for fluid to drain from the middle ear.
Children can use Otovent® at home under parental supervision. It is painless, harmless and takes only a matter of seconds to perform. Otovent® should be used 2-3 times daily until all the fluid has been drained away.

Publications

  1. Point Prevalence of Barotitis and Its Prevention and Treatment with Nasal Balloon Infl ation: A Prospective, Controlled Study. Stangerup SE, Klokker M, Vesterhauge S, Jayaraj S, Rea P, Harcourt J, Otol Neurotol 25:89-94,2004.
  2. Point prevalence of barotitis in children and adults after flight, and effect of autoinflation. Stangerup SE, Tjernström O, Klokker M, Harcourt J, Stokholm J. Aviat Space Environ Med. 1998 Jan;69(1):45-49.
  3. Non surgical treatment of otitis media with effusion. Hanner P. Indian Journal of Otology Vol.3, No.3 (Sept.97), 101-107.
  4. Barotitis in children after aviation; prevalence and treatment with Otovent. Stangerup SE, Tjernstrom O, Harcourt J, Klokker M, Stokholm J. J Laryngol Otol. 1996 Jul;110(7):625-628.
  5. Conservative treatment of otitis media with effusion by autoinflation of the middle ear. Blanshard JD, Maw AR, Bawden R. Clin Otolaryngol Allied Sci. 1993 Jun;18(3):188-92.
  6. Autoinflation as a Tretmentof Secretory Otitis Media. S. E. STANGERUP, MD;J. Sederberg-Olsen, MD; V. Balle, MD. Arch Otolaryngol head Neck Surg. 1992;118:149-152
  7. Effect of nasal balloon autoinflation in children with otitis media with effusion in primary care. Williamson I, CMAJ Sept. 22,2015 967-969
C
Austrian otologist, born October 1, 1835, Alberti, Hungary; died August 10, 1920, Vienna.

Biography of Adam Politzer

Adam Politzer was born in Albertirsa, about 35 km from Budapest. Little is known about his background, except that his father was a well-to-do Jewish merchant (some say he was a teacher), his grandfather a surgeon. As a young man he developed interests in both languages, particularly Latin and Italian, and science. He also had a love of art and had a great deal of artistic talent.
He studied in Vienna, particularly under Josef Skoda (1805-1881), Karl von Rokitansky (1804-1878), Johann Ritter von Oppolzer (1808-1871), and Carl Ludwig (1816-11895). Johann von Oppolzer was a professor who took special interest in Politzer. Oppolzer was an internist who made sickbed teaching, for which the Vienna School was known, so popular. Politzer received his doctorate at Vienna in 1859 and subsequently worked in Carl Ludwig's laboratory, where he undertook experiments in the physical principles involved in the auditory system. It was in Ludwig's laboratory that he introduced the method known as politzerisation. Politzer published his findings in 1861. Due to this experiment, practitioners were now able to treat ear diseases through his innovation of politzerisation rather than trying to do the difficult procedure of passing a catheter into the torus of the eustachian tube. Worldwide use of the politzerisation technique thus made Politzer very well known.
Politzer then trained with Anton Friedrich Freiherr von Troeltsch (1829–1890 in Würzburg, Hermann Ludwig Ferdinand von Helmholtz (1821–1894) in Heidelberg, Claude Bernard (1813–1878) in Paris, and with Karl Rudolf König. Later, under the tutelage of Rudolf Albert von Kölliker (1817–1905) in Würzburg, and Joseph Toynbee (1815–1866) in London, Politzer learned microscopy.

Already four years after graduation, in 1863 he established the first clinic in the world devoted to the treatment of ear diseases. He was joined by Josef Gruber (1827–1900), who was in charge of the male patients, while Politzer housed a ward with only female patients. Politzer became a Dozent of otology at the University of Vienna in 1861, and ausserordentlicher professor of otology in 1870. The same title was awarded Josef Gruber. The two worked jointly, but not without friction, and when The University of Vienna Aural Clinic (Allgemeines Krankenhaus) was established in 1871, Adam Politzer and Josef Gruber were again promoted and appointed joint directors.
His teaching soon attracted large audiences. In 1873 he took over leadership of the university otological clinic at the Wiener allgemeines Krankenhaus, the first specialised otological clinic in the world, and lectured there from 1894 to 1906, becoming full professor in 1895, sole leader from 1898. Besides his hospital and university duties, Politzer attended his private clinic, which attracted patients from all over the world. In order to obtain a larger material for study, Politzer in 1864 persuaded the mayor of Vienna, Dr. Seeler, to allow him to treat indigent ear patients at the charity hospital, along with the population of the local home for the elderly. Politzer retired in 1907. At his retirement celebration 500 physicians from around the world showed up.
Politzer left the University og Vienna a fine collection of pathological-anatomical specimens of the hearing organ. However, he died in poverty, due to personal financial problems and the devaluation of Austrian currency after WWI. The financial situation in Austria at the time was similar to that of Germany a few years later, and no less devastating.

 ON SALE IN USA NOT CANADA
USA Invotec-International www.otovent.net

24 September 2015

DAILY MAIL SAYANA PRESS (MEDROXYPROGESTERONE ACETATE) CONTRACEPTIVE INJECTION (PFIZER) FREE IN UK FROM AGE 12y.

Contraceptive jab on the NHS that you inject at home: Free treatment will be available from GPs and family planning clinics as an alternative to the Pill 

  • A DIY contraceptive jab is to be offered to young women for free on NHS
  • It will be available from GPs or family planning clinics as alternative to Pill
  • Women to be shown how to administer injection but can give it themselves

Young women will today be offered a DIY contraceptive jab for free on the health service.
The jab, which they can give themselves at home, will be available from GPs or family planning clinics as a convenient alternative to the Pill.
Women will be first shown exactly how to administer the injection by a nurse or doctor.
It has to be topped up every three months and they will be given a supply to last them up to a year, after which time they will be advised to have a check-up.
In theory, GPs could prescribe the jab to girls as young as 12 but this is unlikely, given the responsibilities involved in self-administering it.
Manufacturers are instead aiming it at busy women in their twenties and thirties as an alternative to the Pill, which many forget to take.
Side effects include weight gain and some studies have found that a third of users put on more than 2kg (4.5lb) in the first year.
Others suffer sickness, abdominal pain and headaches and, in very rare cases, bone thinning.
Campaigners also fear that some prescriptions will be handed to schoolgirls, who may then share them with friends.
The injection – called Sayana Press – works by releasing a steady supply of the naturally-occurring hormone progesterone into the bloodstream. This prevents the woman releasing an egg and thickens the entrance to the womb making it more difficult for the sperm to enter.
It also thins the lining of the womb, meaning it would be less able to support a fertilised egg.
Women inject it into their thighs or abdomen every 13 weeks, although it may take up to seven days to be effective.
The injection is already available if carried out by a doctor or nurse but the drugs regulator, the Medicines and Healthcare Products Regulatory Agency, has just given it a licence to be administered at home.
Manufacturer Pfizer believes this will benefit many women by sparing them the hassle of having to make an appointment every three months. They say it will cost the NHS around £6.90 per jab or £27.60 for a year.
It is only available on prescription so, although it technically has a licence to be used in girls aged 12 to 18, it is unlikely GPs would recommend it.
Doctors would need to be sure the women were responsible enough to inject themselves properly and remember to top up every three months.
The DIY jab, which women can give themselves at home, will be available from GPs or family planning clinics as an alternative to the Pill (file photo)
The DIY jab, which women can give themselves at home, will be available from GPs or family planning clinics as an alternative to the Pill (file photo)
Seema Patel of Pfizer UK said: ‘We appreciate that many women are very busy and that visiting their healthcare professional regularly to pick up their contraception can be a challenge.
‘With around 5million women in the UK choosing a hormonal contraceptive, self-injectable Sayana Press could offer an alternative to those who are short on time yet still want to take control of their family planning.’
Professor Jane Anderson, sexual health chief at Public Health England said: ‘It is important that women have a choice of contraceptives to fit in with their personal lifestyle and routine.’
But Norman Wells, of the Family Education Trust, said: ‘The manufacturers may claim that this new product will only be prescribed to underage girls in exceptional circumstances, but in this area of medicine the exception all too quickly becomes much more common.
‘As with other forms of contraception, prescribing self-injectable contraceptives to schoolgirls is effectively giving them a licence to engage in illegal sexual activity and robbing them of the protection that the law on the age of consent is intended to give.’
He also warned parents would be left ‘completely in the dark’ if girls were using the jab because doctors cannot tell them due to patient confidentiality.

Read more: http://www.dailymail.co.uk/health/article-3247001/Contraceptive-jab-NHS-inject-home.html#ixzz3mfeOV8dH
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PFIZER COMMENT
Use of SAYANA® PRESS is associated with significant loss of bone mineral density (BMD). This loss of BMD is of particular concern during adolescence and early adulthood, a critical period of bone accretion. Decrease in BMD during treatment appears to be substantially reversible after depot medroxyprogesterone acetate (DMPA) injection is discontinued. 

21 September 2015

UK DAILY MAIL: SWISS firm TURING PHARM AB bought Marketing Rights to DARAPRIM (PYRIMETHAMINE)

  • Martin Shkreli, 32, founder and chief executive of Turing Pharmaceuticals, purchased the rights to Daraprim in August for $55million
  • He raised the price of the drug form $13.50 per tablet to $750 per tablet
  • Shkreli has backed the decision, saying that his company 'need to turn a profit on the drug'
  • Daraprim treats toxoplasmois, an opportunistic parasitic infection that can cause serious and life-threatening problems

Globe and Mail::Couple shot at expensive steakhouse MICHAEL'S ON SIMCOE.10pm Sunday (yesterday)

Two masked persons shot two diners at walk-in MICHAEL'S.100 Simcoe (W.of University;S on Adelaide)

Well-known steakhouse with ANGUS & KOBE beef.

Left-wing pressure on Toronto police to be kind to criminals.

Safest to eat in HOTELS with entrance`away from restaurant. Increasing violent crime in Toronto. .


19 September 2015

UK DAILY MAIL : Man swallows 35 tabs SILDENAFIL for a dare. Five days in hospital. NHS pays.

Plasterer who took 35 Viagra pills for a dare ends up spending a week in bed 

  • Daniel Medforth, from Withernsea in East Yorks, took the pills 'for a laugh' 
  • After taking ill he confessed to his wife and she phoned the ambulance
  • Medical staff who treated the 36-year-old tried hard not to laugh at him
  • Mr Medforth was forced to stay in bed for days due to constant erections

A man took 35 Viagra pills (comment: 25, 50 or 100mg not stated) in an hour for a dare and ended up in hospital with constant erections for five days.
Daniel Medforth, from Withernsea in East Yorkshire, took the pills 'for a laugh'.
After taking ill because of the overdose the father-of-two confessed to his wife, who was shocked by what he had done and called an ambulance.

17 September 2015

DAILY MAIL; TB IN UK SCHOOL

Nearly 200 children are treated for infection after a major outbreak of tuberculosis at a British school 

  • Almost 200 pupils have tested positive for TB at Teign School in Devon 
  • Follows two confirmed ... at same school last year
  • Around ten needed treatment for 'active' TB and all predicted to recover  
Almost 200 children were infected with tuberculosis following a major outbreak at a Devon school, it was revealed today.
Health bosses revealed the results of a major TB screening programme when all pupils were tested at Teign School near Newton Abbot after two caught the infectious disease.
One is a current pupil and one a student who left in 2014 - both were successfully treated and are no longer infectious.
Public Health England subsequently tested 1,400 pupils and staff with a total of 200 giving a 'positive screening.' 
TB is an infection that usually affects the lungs. It is passed on through coughs and sneezes among people who have been in close contact.
Screening: Almost 200 pupils at Teign School near Newton Abbot were found to have TB after two others caught the infectious disease
Screening: Almost 200 pupils at Teign School near Newton Abbot were found to have TB after two others caught the infectious disease
PHE said fewer than 10 needed treatment for 'active TB' and they were all diagnosed within the early stages.
The 200 pupils who had been infected did not have TB disease and were not infectious. They received treatment for a latent TB infection to stop any spread of it in the future.
The numbers testing positive was described as 'unusual' but the pattern of spread is reportedly consistent with contact with an infectious person during the 2013/14 school year.
The situation is now described as being 'under control' and the risk of further infection within the school is currently no greater than that in the general public.
In 2011 TB cases reached a new high in the UK with 8,963 people diagnosed. Rates of TB in the UK are now stabilising, with about 8,000 cases reported annually.

The UK has the second highest rate of TB among western European countries and rates are nearly five times higher than in the US. 
TB is a bacterial infection which is spread by inhaling drops of saliva when an infected person coughs, speaks or sneezes.
The disease mainly affects the lungs, but can travel to other parts of the body including the brain, kidneys, bones and joints. 
The disease is curable with a six-month course of antibiotics, but a drug-resistant form can develop if the course is not completed. 
Left untreated it can prove fatal.
Symptoms include a persistent cough that lasts for more than three weeks that gets progressively worse, unexplained weight loss, fever, night sweats, chest pain, fatigue and loss of appetite.
However, many people who are infected never develop symptoms - although the bacteria remain in the body, they are not infectious.
NHS England said in 2013 there were 7,290 cases of TB reported across England - about 13.5 cases per 100,000 of the population.
The UK has the second highest rate of TB among western European countries and rates are nearly five times higher than in the US. 
TB that affects the lungs is the most contagious type, but it usually only spreads after prolonged exposure to someone with the illness - and in those cases could be deadly.
Dr Sarah Harrison, Deputy Director of Health Protection for Public Health England South West, said: 'We are pleased to say that the investigation is nearing competition and only a small number of people are still to be tested and continue to be followed up.
'The situation is under control and the risk of further infection within the school is now no greater than that in the general public.
'The year groups primarily affected were those of the two students with infectious TB.
'We did not find evidence of significant transmission affecting the Sixth Form during 2013/14 or Year 7 in 2014/15.
'Of those screened as school contacts, fewer than 10 people are being treated for active TB. These were all diagnosed in the early stages of disease.. There have been no further infectious cases at the school.
'Consequently, we do not anticipate the need for any further screening at the school and it can continue to operate as normal.
'We would like to thank the school for being very supportive and providing a huge amount of assistance to ensure that the screening ran smoothly.
'There was a tremendous response to the screening days with a high uptake of the test.
'We also worked closely with the TB Support Team at Torbay Hospital and are very grateful for their support and the enormous effort made by the Hospital to follow up those who tested positive.'