Obstet Gynecol. 1986 Sep;68(3 Suppl):37S-39S.
Elsberg syndrome: a neurologic basis for acute urinary retention in patients with genital herpes.
Hemrika DJ, Schutte MF, Bleker OP.
Abstract
Three patients with genital herpes simplex type II primoinfection and acute urinary retention are described. All patients showed pleocytosis of the cerebrospinal fluid, substantiating central nervous involvement. The association of genital herpes and sacral (myelo-) radiculitis has gained little attention in gynecologic literature, yet it is not an uncommon finding in female patients suffering from herpes. The present report emphasizes the importance of urinary symptoms in genital herpes and reviews the literature on similar cases.
PMID: 3737073 [PubMed - indexed for MEDLINE]
World-wide medical news for clinical use. Contributions edited by Dr.A.Franklin MBBS(Lond)Dip.Phys.Med (UK) DPH & DIH(Tor.)LMC(C) FLEx(USA) Fellow Med.Soc.London
16 August 2011
UK: 14 months prison for knowingly transmitting geniital HERPES
Tuesday, Aug 16 2011 12PM 66°F 3PM 68°F 5-Day Forecast
Traffic officer jailed for 14 months after giving his girlfriend HERPES
- Sexual health charities brand decision as 'outrageous'
By Daily Mail Reporter
Last updated at 1:02 PM on 16th August 2011
David Golding, 28, admitted causing grievous bodily harm after giving his ex-partner genital herpes during their relationship.
Northampton Crown Court heard traffic officer Golding kept quiet about his STD when the couple got together in 2009.
Justice? David Golding was jailed for 14 months at Northampton Crown Court (right)
Leading charities have described the decision to lock up Golding, of Daventry, Northamptonshire, for 14 months as 'outrageous'.
But Judge Michael Fowler said Golding's initial refusal to admit passing on herpes 'placed uncertainty in her life and caused suspicions to be cast onto others'.
He added: 'The offence to which you have pleaded guilty invariably causes great concern.
'Because it was in a relationship, it was particularly mean and one which amounted to a betrayal - a betrayal in a relationship in which you professed love.
'The injury you caused her by this infection is at least as or more serious than an injury leaving a scar because it carries continued recurrence, extreme discomfort and consequences for relationships she will have in the future.'
Prosecutor Steven Evans told the court Golding, a traffic officer for the Highways Agency, initially denied carrying the disease when confronted by his lover in September 2009.
The Herpes virus causes outbreaks of painful sores
'She said she would not have slept with him had she known, even with contraception.
'The relationship had continued beyond the revelation and him having transferred the infection to her for some months into early 2010.
'Following the breakdown of relations between the two of them she reported it to the police.'
David Everett, mitigating, said: 'He was stupid, extremely stupid but he did not do this in a premeditated way.'
Nigel Scott, of the Herpes Viruses Association, said there are around 75,000 new cases of the STD every year.
He said: 'Will children also now be prosecuted for giving their friends chicken pox? For passing on a cold sore? This is outrageous.
'This case sets back the normalisation of this trivial infection by years. I had thought such a farcical scenario could only happen in America, never in Northampton.'
Marian Nicholson, director of the Herpes Viruses Association added:
'It is unfortunate genital herpes is being dragged in to court like this.
'This is a very common virus, herpes simplex, that most of us carry without even noticing.'
Herpes can cause a recurring flu-like virus, which is followed by an outbreak of painful oral or genital sores in many sufferers.
Read more: http://www.dailymail.co.uk/news/article-2026598/Man-jailed-14-months-giving-girlfriend-HERPES.html#ixzz1VC3CNsDx
15 August 2011
TOCILIZUMAB: RoActemra(UK) ACTEMRA (ROCHE) aproved in UK for Juvenile RA.
ROCHE RoACTEMRA approved in UK for Juvenile RA.
ROCHE multi-country ACTEMRA trial on Ankylosing Spondylitis not yet published.
DRUG cost of 400mg MONTHLY sub.cut infusion $1700. (4-8mg/kg).
ROCHE multi-country ACTEMRA trial on Ankylosing Spondylitis not yet published.
DRUG cost of 400mg MONTHLY sub.cut infusion $1700. (4-8mg/kg).
UK IMPERIAL COLLEGE,LONDON. BIOMEDICAL ENGINEERING
SEE COMMENT FOR DETAILS
14 August 2011
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UK Death from Extrinsic Allergic Alveolitis
from UK DAILY MAIL
Warder killed by inhaling fumes from droppings of prisoners' 'pet' pigeons
By Christopher LeakeLast updated at 11:18 PM on 13th August 2011
Prison Warder Steve Burks died of a lung disease caused by the droppings of inmates' pigeons
Steve Burks, 54, was claiming damages from the Prison Service and the Ministry of Justice but died from the disease, caused by inhaling fumes from pigeons’ droppings, before his case was settled.
Now the Prison Officers’ Association (POA) is helping Mr Burks’s widow Lynda pursue her husband’s claim as well as demanding jails bring in new safety procedures.
Mr Burks, from Southampton, was awaiting a lung transplant but died in April from extrinsic allergic alveolitis, commonly known as ‘bird fancier’s lung’.
An inquest ruled this month that the disease was caused by his exposure to pigeon waste during his job.
Two months before his death, Mr Burks – who was forced to retire early on medical grounds from his job at Winchester Prison – described how he had suffered because of ‘an invisible, life-threatening hazard’.
Writing in his union’s journal, Mr Burks told how he had to use an oxygen supply, could hardly walk because he was so breathless and was forced to take 12 tablets a day.
Mr Burks, who had never bred or raised pigeons, urged colleagues to wear safety gloves or a mask after claiming his own prison managers had failed to give him proper advice.
He said: ‘My lungs are inflamed and covered in shadows. My oxygen levels are so low that I require oxygen 20 hours a day.
My quality of life is zero. I can’t walk very far without getting breathless. I struggle to get dressed and get in and out of the bath. The stairs are an absolute killer to climb.
‘Don’t let management fob you off saying there is no risk from these flying pests, because clearly there is.’
His widow Lynda said: ‘I am very bitter and angry over what happened. He was suing the Ministry of Justice and he felt so angry and this has completely devastated me.’
Workplace: Mr Burks was a warder at Winchester Prison
It is very possible other officers have died from the same disease without it being realised. It could be like the asbestos issue. We want action to prevent it happening again.’
Mr Traynor said that because prisoners coaxed pigeons to their cell windows and treated them as pets, they also risked contracting the disease.
He added: ‘Once you have prisons, you have pigeons. We have a major problem in all our establishments.’
He suggested using decoy owls to scare pigeons away or putting spikes on window sills.
Professor Stephen Spiro, deputy chairman of the British Lung Foundation, urged prisoners not to feed pigeons. He said: ‘If they are fed, they will come in numbers.’
He warned that people feeding pigeons in places such as Trafalgar Square are also at risk.
A spokesman at the Ministry of Justice said: ‘We cannot comment on ongoing legal proceedings. We take the health and welfare of staff and prisoners very seriously.’
Read more: http://www.dailymail.co.uk/news/article-2025687/Warder-killed-inhaling-fumes-droppings-prisoners-pet-pigeons.html#ixzz1V1NAUMkL
13 August 2011
FRANCE: ANTI-BIOTERRORISM RESEARCH against RICIN.
Inhibition of Retrograde Transport Protects Mice from Lethal Ricin Challenge
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Cell, Volume 141, Issue 2, 231-242, 16 April 2010
Copyright
2010 Elsevier Inc. All rights reserved.
10.1016/j.cell.2010.01.043
Copyright
10.1016/j.cell.2010.01.043
Referred to by: Ricin Toxin Hits a Retrograde Roadblock
Authors
Bahne Stechmann, Siau-Kun Bai, Emilie Gobbo, Roman Lopez, Goulven Merer, Suzy Pinchard, Laetitia Panigai, Danièle Tenza, Graça Raposo, Bruno Beaumelle, Didier Sauvaire, Daniel Gillet
, Ludger Johannes
, Julien BarbierSee Affiliations
Traffic, Signaling, and Delivery Laboratory, Centre de Recherche, Institut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France Structure and Membrane Compartments Laboratory, Centre de Recherche, Institut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France Cell and Tissue Imaging Facility (Infrastructures en Biologie Sante et Agronomie), Centre de Recherche, Institut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France Unité Mixte de Recherche 144, Centre National de la Recherche Scientifique, France Laboratoire de Toxinologie Moleculaire et Biotechnologies, Service d'Ingenierie Moleculaire des Proteines, Institut de Biologie et de Technologies de Saclay, Direction des Sciences du Vivant, Commissariat a l'Energie Atomique et aux Energies Alternatives, F-91191 Gif sur Yvette, France Laboratoire de Chimie Bioorganique, Service de Chimie Bio-organique et de Marquage, Institut de Biologie et de Technologies de Saclay, Direction des Sciences du Vivant, Commissariat a l'Energie Atomique et aux Energies Alternatives, F-91191 Gif sur Yvette, France Unite Controles de Bioactivite et Radioanalyse, French Health Products Safety Agency (Afssaps French Official Medicines Control Laboratory), Direction des Laboratoires et des Controles, 635 rue de la Garenne, 34740 Vendargues, France Centre d'etudes d'agents Pathogenes et Biotechnologies pour la Sante, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5236, Case 100, Université Montpellier 2, 34095 Montpellier, France Corresponding author
- Highlights
- Identification of two toxin inhibitors by cell-based high-throughput screening
- Cells are protected against the plant toxin ricin and bacterial Shiga-like toxins
- Inhibitors selectively block toxin trafficking at endosome-TGN interface
- One compound protects mice from lethal nasal challenge with ricin
Summary
Bacterial Shiga-like toxins are virulence factors that constitute a significant public health threat worldwide, and the plant toxin ricin is a potential bioterror weapon. To gain access to their cytosolic target, ribosomal RNA, these toxins follow the retrograde transport route from the plasma membrane to the endoplasmic reticulum, via endosomes and the Golgi apparatus. Here, we used high-throughput screening to identify small molecule inhibitors that protect cells from ricin and Shiga-like toxins. We identified two compounds that selectively block retrograde toxin trafficking at the early endosome-TGN interface, without affecting compartment morphology, endogenous retrograde cargos, or other trafficking steps, demonstrating an unexpected degree of selectivity and lack of toxicity. In mice, one compound clearly protects from lethal nasal exposure to ricin. Our work discovers the first small molecule that shows efficacy against ricin in animal experiments and identifies the retrograde route as a potential therapeutic target.
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