30 November 2011

ONTARIO: Govt pays for Serum Free Light Chain Analysis in selected Cancer units.

Serum Light Chain Analysis available PRIVATELY in Ontario @ $300 plus Courier service. Govt. pays in selected Cancer clinics.

Monitoring patients with monoclonal light chain diseases but no M-spike on protein electrophoresis


Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory testThe monoclonal gammopathies are characterized by a clonal expansion of plasma cells that secrete a monoclonal immunoglobulin (Ig). The monoclonal Ig secreted by these cells serves as a marker of the clonal proliferation, and the quantitation of monoclonal protein can be used to monitor the disease course.


The monoclonal gammopathies include multiple myeloma (MM), light chain multiple myeloma (LCMM), Waldenstrom’s macroglobulinemia (WM), nonsecretory myeloma (NSMM), smoldering multiple myeloma (SMM), monoclonal gammopathy of undetermined significance (MGUS), primary systemic amyloidosis (AL), and light chain deposition disease (LCDD).



Monoclonal proteins are typically detected by serum protein electrophoresis (SPEP) and immunofixation (IF). However, the monoclonal light chain diseases (LCMM, AL, LCDD) and NSMM often do not have serum monoclonal proteins in high enough concentration to be detected and quantitated by SPEP.


A sensitive nephelometric assay specific for kappa free light chain (FLC) that doesn’t recognize light chains bound to Ig heavy chains has recently been described. This automated, nephelometric assay is reported to be more sensitive than IF for detection of monoclonal FLC. In some patients with NSMM, AL, or LCDD the FLC assay provides a positive identification of a monoclonal serum light chain when the serum IF is negative. In addition, the quantitation of FLC has been correlated with disease activity in patients with NSMM and AL.

See Laboratory Approach to the Diagnosis of Amyloidosis and Laboratory Screening Tests for Suspected Multiple Myeloma in Special Instructions.



Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.KAPPA-FREE LIGHT CHAIN
0.33-1.94 mg/dL


LAMBDA-FREE LIGHT CHAIN
0.57-2.63 mg/dL


KAPPA/LAMBDA FLC RATIO
0.26-1.65



Interpretation Provides information to assist in interpretation of the test resultsThe specificity of this assay for detection of monoclonal light chains relies on the ratio of free kappa and lambda light chains. Once an abnormal free light chain (FLC) K/L ratio has been demonstrated and a diagnosis has been made, the quantitation of the monoclonal light chain is useful for monitoring disease activity.



Changes in FLC quantitation reflect changes in the size of the monoclonal plasma cell population. Our experience to date is limited, but changes of >25% or trending of multiple specimens are needed to conclude biological significance.



Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substancesElevated kappa and lambda free light chain (FLC) may occur due to polyclonal hypergammaglobulinemia or impaired renal clearance. A specific increase in FLC (eg, FLC K/L ratio) must be demonstrated for diagnostic purposes.


Moderate to marked lipemia may interfere with the ability to perform testing.


Supportive Data

Studies at Mayo Clinic have shown that in some patients with urine monoclonal light chains and negative serum immunofixation (IF), the free light chain (FLC) assay can identify monoclonal FLC in the serum. These studies support the increased sensitivity of the nephelometric FLC assay. In a series of patients with primary systemic amyloid treated by stem cell transplantation, the quantitation and monitoring of FLC predicted organ response (eg, disease course).



Clinical Reference Provides recommendations for further in-depth reading of a clinical natureDrayson M, Tang LX, Drew R, et al: Serum free light chain measurements for identifying and monitoring patients with nonsecretory multiple myeloma. Blood 2001;97(9):2900-2902

29 November 2011

UK DAILY MAIL: COST of AIDS

MOUNTING COSTS OF HIV TREATMENT


The cost of treating someone with HIV in the UK is estimated to be around £18,000 per year when they are not showing any symptoms.



This is based on the price of care as well as triple-drug antiretroviral therapy.





However, it costs £21,500 to treat patients who are showing symptoms and £41,000 for those with full-blown AIDS.



Patients who have four drugs cost the NHS between £22,775 and £48,000 per year.



The annual cost of providing HIV treatment and care in the UK could be as high as £758 million by 2013, according to a study in PLoS One.



Read more: http://www.dailymail.co.uk/health/article-2067496/Number-people-HIV-UK-poised-hit-100-000-infections-rise-6-year.html#ixzz1f6DXIu6F

24 November 2011

UK DAILY MAIL Swedish AIRSONETT Inc. PROTEXO Temperature controlled Laminar airflow

By Daily Mail Reporter

Children with asthma are taking part in a trial to see if the Airsonett machine, which sucks up dust, can reduce their symptoms

A machine that hangs over the bed cleaning the surrounding air could ease night-time wheezing for asthmatics.

The so-called 'air vacuum' sucks up allergens and dust particles that could trigger attacks.

The £2,000 Airsonett machine uses the same technology deployed by manufacturing industries to create sterile environments by removing dust particles from the air.

Now a trial is under way at St Mary's Hospital in London involving 75 children with asthma to see if the device can reduce their symptoms.

 More than five million people in the UK suffer with asthma, including at least one million children.

The year-long trial, due to end next summer, is comparing real 'air vacuum' machines with dummy ones.

Read more: http://www.dailymail.co.uk/health/article-1077369/Could-vacuum-sucks-allergens-stop-night-time-wheezing-asthma-sufferers.html#ixzz1efi515z7

http://www.airsonett.com/

19 November 2011

COCKROACH SENSITIVITY in Allergic Rhinitis.

POSTER PRESENTATION Open Access


Cockroach sensitivity in allergic rhinitis patients;

is it significant? To see prevalence of cockroach

sensitivity in allergic rhinitis patients in

Kingston area

Tahira Batool*, Rozita Borici-Mazi

From Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2010

Victoria, Canada. 3-6 November 2010

Background

Role of cockroach allergy in asthma has been widely studied

and the effect of environmental control on asthma

symptoms has been established. However, the role of

cockroach sensitivity remains unknown. We have

designed this study to establish role of cockroach sensitization

on allergic rhinitis.

Hypothesis

Cockroach allergy has significant role in allergic rhinitis.

Population

Allergic rhinitis patients attending allergy and clinical

immunology clinic under Dr Rozita Borici-Mazi in Kingston

General Hospital, Kingston ON.

Method

Retrospective chart review of patients evaluated for

allergic rhinitis and underwent skin prick testing.

A cohort of 250 patients was randomly selected with

inclusion criteria being symptomatic allergic rhinitis and

positive allergy skin prick testing to usual panel of allergens.

Data collection included demographics, smoking

exposure, symptom pattern, presence or absence of

non-nasal symptoms, positive skin prick testing for

cockroach and other environmental allergens such as

dust mite, cat, dog, and seasonal pollens.

Results

Allergy to seasonal allergens was found to be the most

common (n=191, 76.4%) followed by house dust mite

(n=149, 59.6%) and cat allergen (n=118, 47.2%). Cockroach

sensitization was found in 62 (25%). Among the

cockroach sensitivity group, 8 patients had monosensitization

to cockroach. All of them had perennial symptoms.

75%of these people were residents of urban areas.

Two patients who had symptoms for more than 8 years

had developed asthma.

Conclusion

Cockroach allergy is found to be one of the significant

indoor allergens in allergic rhinitis in Kingston area.

Given the relationship of Allergic Rhinitis and Asthma

development, there is need to recognize this important

allergen earlier and treat it through allergen avoidance

and/or Immunotherapy, not only to treat allergic rhinitis

symptoms but also to prevent development of allergic

asthma. Further studies to establish the correlation

between allergic rhinitis and cockroach sensitization are

needed.

Published: 4 November 2010

doi:10.1186/1710-1492-6-S2-P11

Cite this article as: Batool and Borici-Mazi: Cockroach sensitivity in

allergic rhinitis patients; is it significant? To see prevalence of cockroach

sensitivity in allergic rhinitis patients in Kingston area. Allergy, Asthma &

Clinical Immunology 2010 6(Suppl 2):P11.

* Correspondence: 7TB11@queensu.ca

Department of Internal Medicine, Queen’s University, Kingston, Ontario,




Ann Allergy. 1978 Dec;41(6):333-6.


A comparative study of prevalence of skin hypersensitivity to cockroach and house dust antigens.

Kang B, Sulit N.

Abstract

Allergy skin tests with cockroach antigen along with various common inhalant allergens were performed on 222 atopic and on 63 non-atopic subjects. The most prevalent allergen producing a positive skin test was house dust antigen with a positive response of 72%, 78% and 57% in atopic adults, atopic children and non-atopic children, respectively. The next prevalent positive skin test was to cockroach antigen with 50%, 60% and 27%, respectively, of the three groups tested. The differences between positive cockroach hypersensitivity and house dust hypersensitivity in all three groups tested were statistically significant. Next in order of prevalence of positive skin test to common inhalants were western weeds, ragweeds and cats. Incidence of cockroach hypersensitivity was 58% among asthmatic adults and 69% among asthmatic children. The results indicate that cockroach hypersensitivity is highly prevalent and that cockroach antigen is an independent agent from house dust as a cause of immediate hypersensitivity reaction.



PMID: 569451 [PubMed - indexed for MEDLINE



WISEMAN RD, WOODIN WG, MILLER HC, MYERS MA. Insect allergy as a possible cause of inhalant sensitivity. J Allergy. 1959 May–Jun;30(3):191–197. [PubMed]

16 November 2011

Dutch Society for Free Will End-of-Life: Mobile Euthanasia Teams

De TELEGRAAF

NVVE lanceert mobiele teams voor euthanasie AMSTERDAM - De Nederlandse Vereniging voor een Vrijwillig Levenseinde (NVVE) wil reizende teams opzetten met gespecialiseerde artsen om bij mensen thuis euthanasie toe te passen. De NVVE doet dit omdat veel zieken en ouderen door artsen niet serieus worden genomen in hun stervenswens, heeft een woordvoerster woensdag laten weten. Volgens de criteria van de euthanasiewet zou deze groep wel in aanmerking komen voor euthanasie, zo stelt de NVVE. Nederland zou het eerste land ter wereld worden met dergelijke ambulante teams.

14 November 2011

BIONIME Inc. TAIWAN - SWISS BLOOD SUGAR TESTER.

Swiss-design elegant pocket phone-like Blood Sugar tester. Easy-to-handle test strips. Swiss designed RIGHTEST GD500 Lancing device. RIGHTEST Control Normal & High blood sugar solution included.

Swiss (injection systems) YPSOMED AG (CEO R.FRITCHI) bought 10% of Taiwan BIONIME Inc. (CEO R.HUANG) for CHF 6.5 million.


產品分類

PRODUCTS



GM100 Series





Acquire“Innovation Award” from Mediphar Taipei

No coding

Noble Metal Electrode Strip

High Accuracy & Precision





GM300 Series





Noble Metal Electrode Strip

Smart Code Key

High Accuracy & Precision

Wide LCD screen







GM210 Series





Noble Metal Electrode Strip

Smart Code Key

High Accuracy & Precision

Wide LCD screen





GM550 Series





Auto coding (Patent Pending)

Backlight

Noble Metal Electrode Strip

High Accuracy & Precision

CANADA: (Quebec) HYGIE "cloth" changes fluid to GEL

HYGIE "cloth" converts fluid to a GEL. Coverts body liquids to a firm gel. Plastic male urinal used by truckers and especially by elderly males to avoid getting up at night; risk of falls and fractures reduced

Sold by Quebec pharmacies.

BAYER point-of-care HbA1c test using capillary blood & "A1CNow+" monitor

A1CNow+®


Fast. Easy. Accurate.

Get A1C test results now in just 5 minutes. The A1CNow+® monitor is hand-held, portable and simple to use. Test results are lab accurate at 99%1.

The A1CNow+® monitor enables you to get rapid A1c test results while your patients are in your office, empowering you to make on-the-spot treatment decisions for your diabetes patients.

Using the A1CNow+® monitor is:

Fast.

In office testing. No waiting for lab results

Results in just five minutes

Hands-on procedure time is less than one minute

Provides opportunity for immediate, face-to-face counseling

Easy.

Simple, 3-step procedure

CLIA waived

Only 5 μL of blood from a fingertip is needed

No calibration, no daily controls, no maintenance

No refrigeration necessary if used within four months

No capital equipment required

Enables A1C testing in every exam room

Accurate.

Proven lab accuracy at 99%

NGSP certified

To learn more about purchasing A1CNow+® for use in your practice, please contact your Bayer sales representative or call our Customer Support Line at 1-800-268-7200.

(In Ontario not covered by Provincial Insurance. Sold by local pharmacies for approx $15 a test.)

11 November 2011

Dusseldorf Heinrich-Heine University Prof N.GATTERMANN MD PhD visits Toronto

Thanks to NOVARTIS sponsorship,  Prof. GATTERMANN gave a series of lectures in Canada on MYELODYSPLASTIC SYNDROME (MDS) with special reference to Non-Transferrin-Bound Iron (NTBI) overload trearted by chelating agents such as deferasirox (Exjade).

Approx. 1800 Canadians are affected by MDS.

The cardiotoxic effect of  NTBI was emphasised.

Ann.Haematol.(2011) 90:1-10 (Springer)
"Iron overload in MDS-pathophysiology,diagnosis, and complications."
N.Gattermann H.H.U. Dusseldorf, Germany   E.Rachmilewitz E.Wolfson Med. Center,Holon, Israel.

Prof Gatterman studied with Late Hepatologist Dame Sheila Sherlock at the Hampstead branch of London's Royal Free Hospital and at the Boston Harvard Medical school. An idiomatically perfect English speaker..

05 November 2011

Ontario College Physicians & Surgeons uses Private investigators with secret cameras.

In three published discipline cases`the CPSO used secret cameras and private investigators.



SPYTECH has`details of hidden cameras.
http://www.spytech.com/



In USA some doctors are recording all patient contacts.



Mini Gadgets CD-PRO Pro Camera Detector $1000

04 November 2011

New Ontario medical rank: GP with FOCUSED PRACTICE in ...

ONTARIO: GP with FOCUSED PRACTICE a copy of UK GPwSI (GP with Special Interest)

Ontario College Phys & Surgeons (CPSO) has copied UK NHS status of "GPwSI"; above basic GP but below a Specialist. GPwSIs often work as hospital clinic assistants to UK Consultants.

CPSO changed the phrase of "Practice Limited to...."

Now "GP with Focused Practice in..."

The "GP" must be included to le4t the public know that the doctor is NOT a Specialist. (The result of the YAZDANFAR case when a GP who did liposuction killed a patient.)



The new`law will help Specialists who trained abroad but can not or will not take the Canadian specialty exams.



It will also help GPs who want to rise above the herd by taking extra courses. It will also help provide a degree of specialised services in parts of Ontario where Specialists do not want to live.



GP Focused Practice Designation: Policy and Program Overview September 2011 Page 34 of 39 Appendix B: Royal College of Physicians and Surgeons of Canada List of Specialties and Subspecialties Adolescent Medicine

Anatomical Pathology

Anaesthesiology

Cardiac Surgery

Cardiology

Clinical Immunology and Allergy

Clinical Pharmacology

Clinician Investigator Program

Colorectal Surgery

Community Medicine

Critical Care Medicine

Dermatology

Developmental Paediatrics

Diagnostic Radiology

Emergency Medicine

Endocrinology and Metabolism

Forensic Pathology

Gastroenterology

General Pathology

General Surgery

General Surgical Oncology

Geriatric Medicine

Gynecologic Oncology

Gynecologic Reproductive Endocrinology and Infertility

Hematological Pathology

Hematology

Infectious Diseases

Internal Medicine

Maternal-Fetal Medicine

Medical Biochemistry

Medical genetics

Medical Microbiology

Medical Oncology

Neonatal-Perinatal Medicine

Nephrology

Neurology

Neuropathology

Neuroradiology

Neurosurgery

Nuclear Medicine

Obstetrics and Gynecology

Occupational medicine

Ophthalmology

Orthopedic Surgery

Otolaryngology-Head and Neck Surgery

Palliative Medicine

Pediatric Emergency Medicine

Pediatric General Surgery