CELL: Yale University ADIPOCYTE LINEAGE CELLS may alter function EPITHELIAL STEM CELL

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Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

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Cell, Volume 146, Issue 5, 761-771, 2 September 2011
Copyright 2011 Elsevier Inc. All rights reserved.
10.1016/j.cell.2011.07.019

Authors

Eric Festa, Jackie Fretz, Ryan Berry, Barbara Schmidt, Matthew Rodeheffer, Mark Horowitz, Valerie HorsleySee Affiliations

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Departments of Molecular, Cell, and Developmental Biology, Yale University, 219 Prospect St., New Haven, CT 06520, USA Orthopdics and Rehabilitation, Yale University, 219 Prospect St., New Haven, CT 06520, USA Section of Comparative Medicine, Yale University, 219 Prospect St., New Haven, CT 06520, USA Yale Stem Cell Center, Yale University, 219 Prospect St., New Haven, CT 06520, USA Molecular Cell Biology, Genetics, and Development Program, Yale University, 219 Prospect St., New Haven, CT 06520, USA Corresponding author

• Highlights
• Resident skin adipocytes regenerate de novo in parallel with the hair cycle
• Immature adipocytes are necessary and sufficient for hair follicle regeneration
• Immature adipocytes express PDGF ligands to promote hair regeneration

Summary

In mammalian skin, multiple types of resident cells are required to create a functional tissue and support tissue homeostasis and regeneration. The cells that compose the epithelial stem cell niche for skin homeostasis and regeneration are not well defined. Here, we identify adipose precursor cells within the skin and demonstrate that their dynamic regeneration parallels the activation of skin stem cells. Functional analysis of adipocyte lineage cells in mice with defects in adipogenesis and in transplantation experiments revealed that intradermal adipocyte lineage cells are necessary and sufficient to drive follicular stem cell activation. Furthermore, we implicate PDGF expression by immature adipocyte cells in the regulation of follicular stem cell activity. These data highlight adipogenic cells as skin niche cells that positively regulate skin stem cell activity, and suggest that adipocyte lineage cells may alter epithelial stem cell function clinically.