29 July 2014

UK DAILY MAIL: PUBLIC HEALTH ENGLAND on EBOLA EPIDEMIC


Dr Paul Cosford, PHE's Medical Director, said: 'This message is to update you on the current outbreak of Ebola virus disease in West Africa, and to remind you of the need to remain vigilant for cases imported to the UK.'
On Monday Public Health England (PHE) issued an alert to GPs, A&E departments, Critical Care Units as well as all NHS trusts across the UK, warning doctors and medical staff to be vigilant to the disease
On Monday Public Health England (PHE) issued an alert to GPs, A&E departments, Critical Care Units as well as all NHS trusts across the UK, warning doctors and medical staff to be vigilant to the disease

21 July 2014

MD ANDERSON: Prof V.Craig JORDAN OBE PhD,DSc(Leeds) Hon.MD(Leeds)

For Immediate Release - July 21, 2014
The “Father of Tamoxifen” to Join MD Anderson
Breast Cancer Research Pioneer V. Craig Jordan, Ph.D., Developer Of Several Cancer-Fighting Drugs, Brings His Translational Research Expertise To Houston
Contact: Ron Gilmore Office: 713-745-1898 Cell: rlgilmore1@mdanderson.org
Contact: Jim Newman Office: 713-792-0664 Cell: jnewman@mdanderson.org
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HOUSTON ― The University of Texas MD Anderson Cancer Center is pleased to announce that one of the world’s preeminent experts in breast cancer research and treatment, V. Craig Jordan, Ph.D., will join the institution’s efforts to end cancer. Jordan is considered the “Father of Tamoxifen,” the groundbreaking therapeutic drug that has saved countless lives.
V. Craig Jordan, Ph.D.
V. Craig Jordan, Ph.D.
As a professor in Breast Medical Oncology and Molecular and Cellular Oncology Jordan will focus on the new biology of estrogen-induced cell death with the goal of developing translational approaches for treating and preventing cancer. He will begin work at MD Anderson in October.
“This is an exciting moment and I’m delighted that Dr. Jordan will be contributing to significant translational research activities in breast cancer here at MD Anderson,” said Ron DePinho, M.D., president of MD Anderson. “His international reputation as a trailblazer in translational research and his many achievements and honors are well deserved. As we progress in our mission of ending cancer in Texas, the nation and the world, it is outstanding scientists like Dr. Jordan who will play key roles in delivering on that promise.”
Jordan’s long and distinguished career has included leadership positions at some of the world’s most prestigious biomedical institutions. Currently, he’s scientific director of the Lombardi Comprehensive Cancer Center at Georgetown University in Washington D.C., and the Vincent T. Lombardi Chair of Translational Cancer Research. He also serves as vice chairman of the Department of Oncology and professor of oncology and pharmacology at Georgetown University’s Medical School. In addition, he’s a visiting professor of molecular medicine at the University of Leeds in England, and an adjunct professor of molecular pharmacology and biological chemistry at Northwestern University in Chicago.
“Dr. Jordan’s election as a member of the National Academy of Sciences in 2009 is just one of the many honors he’s received as a result of his incredible contributions to our understanding of cancer biology,” said Ethan Dmitrovsky, M.D., MD Anderson provost and executive vice president. “MD Anderson is known for bringing the best minds together for the shared purpose of ending cancer. Certainly, a scientist of Dr. Jordan’s caliber adds significantly to our overall research programs. His arrival is due in no small part to the efforts of Debu Tripathy, M.D. and Vicente Valero, M.D."
Dr. Tripathy is MD Anderson’s new Chair of Breast Medical Oncology. He will begin his work at the institution in September.

In addition to his National Academy membership, Jordan’s list of achievements, awards and accomplishments is long, featuring more than four-dozen international awards. The list includes:

  • The St. Gallen Prize for Breast Cancer (2011)
  • The David A. Karnofsky Award from the American Society of Clinical Oncology (2008)
  • The George and Christine Sosnovsky Award in Cancer Therapy (2004)
  • The Charles F. Kettering Prize (2003)
  • The American Cancer Society Medal of Honor (2002)
  • The Dorothy P. Landon Award in Translational Research from the American Association for Cancer Research (2002)
  • The Bristol Myers Squibb Award (2001)
  • The Cameron Prize from the University of Edinburgh (1993)
Jordan has received six honorary fellowships or degrees from universities around the world including an honorary fellowship from the Royal Society of Medicine. In 2010, he was elected president of the Royal Society of Medicine Foundation of North America. Jordan was elected as a Fellow of the Academy of Medical Sciences, the United Kingdom’s equivalent to the Institute of Medicine.
 He has contributed to more than 700 publications, 99 percent of which pertain to cancer research. He has edited 11 books and has more than 26,000 scientific citations. He’s author of the book “Tamoxifen, Pioneering Medicine in Breast Cancer.”
Jordan, who was born in New Braunfels, Texas and raised in England, has dual British and U.S. citizenship. In 2002, he received the Order of the British Empire from Queen Elizabeth II for services to international breast cancer research. He earned a Ph.D. and D.Sc. from the University of Leeds and in 2001 received an honorary M.D. from his alma mater.
“I am proud to join MD Anderson Cancer Center,” said Jordan. “It is indeed an honor to continue my work at this world renowned cancer center where I look forward to working with my distinguished colleagues.”
Jordan is credited with reinventing a failed contraceptive (known as ICI 46,474) as a breast cancer treatment. The drug, in existence since the 1960s, was originally created to block estrogen in the hopes of preventing pregnancy. Jordan developed the strategy of long-term adjuvant tamoxifen therapy, as well as describing and deciphering the properties of a new group of medicines called selective estrogen receptor modulators (SERMs). He was the first to discover the preventive abilities of both tamoxifen and the drug raloxifene. The medicines were approved by the Food and Drug Administration for reducing breast cancer incidence in high-risk women.
Prior to joining Georgetown University, Jordan served on the faculties at Northwestern University Medical School; the University of Wisconsin School of Medicine, Madison, Wis.; the Ludwig Institute for Cancer Research at the University of Berne, Switzerland; and the University of Leeds, England.

19 July 2014

Univ. Amsterdam Prof.Joseph LANGE MD (Ams.1981) PhD(Ams.87) Died: 59y.

Chose to fly on Malaysian Airlines: from Amsterdam to Melbourne for 20th Int. AIDS Conf.

Prof LANGE supported Pre-exposure prophylaxsis (PREP) against HIV. using a combination drug such as TRUVADA (tenofovir + emtricitabine) made by California GILEAD SCIENCES (NASDAQ) Net income 2013 $3-billion.Cost:TRUVADA USD$1,000/month. Reduces HIV incidence by 51%.


18 July 2014

Harvard ProMed: Prevalence GONORRHOEA inceases in NW USA.

GONOCOCCAL DISEASE - USA (03): (IDAHO, OREGON, WASHINGTON) INCREASED
INCIDENCE, RURAL, REQUEST FOR INFORMATION
******************************
********************************************************************************
A ProMED-mail post
<http://www.promedmail.org>
ProMED-mail is a program of the
International Society for Infectious Diseases
<http://www.isid.org>

Date: Wed 16 Jul 2014
Source: KPLU News [edited]
<http://www.kplu.org/post/northwest-health-officials-see-gonorrhea-rising-outside-urban-hubs>



Public health officials in the Northwest [USA] say they're seeing
gonorrhea infections at levels they haven't seen in years; 3 counties
in Washington State are now in the midst of an outbreak, and parts of
Oregon and Idaho are set to top even last year's [2013] high numbers.
Health departments are seeing some unusual trends in the data.

Washington [State] public health officials say King County [which
contains the city of Seattle] often drives statewide trends, just
through the sheer heft of Seattle's urban population. But the 31
percent increase in gonorrhea cases over last year has largely been
from spikes in Snohomish, Spokane and Yakima counties.

Oregon is seeing increases in unexpected places, too. "We've seen,
during the last year and a half [2013-2014], increases in counties
that are more rural than our metropolitan area of Portland," said Dr.
Sean Schafer of the Oregon Health Authority. That includes places like
Jackson, Douglas and Lane counties. Schafer said he hasn't seen such a
high overall gonorrhea in Oregon since the early 1990s.

Idaho's usually low gonorrhea numbers have risen dramatically as well.
The infection rate around the Boise [Ada County] area has more than
doubled since just 2 years ago [2012]. North Idaho, far southwest
Idaho and the Magic Valley have also seen sharp increases. The cause
remains a mystery. One theory is the cyclical nature of the disease.
Another points to the higher rate of meth use in some rural areas.
["Meth" is methamphetamine, a drug used illegally to increase sexual
desire, lift the mood, and increase energy - Wiki. - Mod.JW]

Health departments are working with doctors to increase screening for
the disease and are encouraging people to practice safe sex.

The Northwest's rates -- at around 20-50 cases per 100 000 people --
are still better than the rest of the country, which hovers around 100
per 100 000 people. But health officials say the increase comes at a
time when there are signs gonorrhea bacteria could become resistant to
the last remaining oral antibiotic treatment.

People who get gonorrhea, and women in particular, may have few
symptoms. If left unchecked, it can cause pelvic inflammatory disease
in women and increase the risk of tubal pregnancy. In both men and
women, it has led to infertility in rare cases.

--
Communicated by:
ProMED-mail from HealthMap Alerts
<promed@promedmail.org>

[The above news article reports that the recent increases in the
incidence of gonococcal disease in the contiguous Pacific northwestern
US states of Idaho, Oregon and Washington are occurring in more rural
counties, as well as in more densely populated urban centers. The
article says that the cause remains a mystery, but fails to
characterize the cases of gonococcal disease as to age, sex, sex
behavior, or abuse of drugs [apart from a possible connection with
meth], social networking Internet sites, and smartphone apps, factors
that may contribute to the outbreak.

In Washington State, the counties with increases in numbers of
gonococcal cases were Snohomish, Spokane, and Yakima. Snohomish, in
the western part of the state, is the 3rd-most populous county in the
state; it is located just north of King County, which is the most
populous county in the state and is where the city of Seattle is
located. King County is 47th among US counties with the highest number
of cases of gonococcal disease in 2012
(<http://www.cdc.gov/std/stats12/tables/20.htm>). Spokane, in the
eastern part of the state on the border with northern Idaho, is the
4th-most populous county in the state. Yakima is located in an
agricultural region in south-central Washington State
(<http://en.wikipedia.org/wiki/Yakima_County,_Washington>).

In Oregon, the rural counties with increases in gonococcal cases were
Jackson, Douglas and Lane; they are contiguous counties in the
southwestern part of the state. However, the city of Eugene in Lane
County is the 2nd most populous city in the state
(<http://www.portland.com/largest-cities.aspx>) and is home to the
University of Oregon (<http://en.wikipedia.org/wiki/Eugene,_Oregon>),
which may account for some of this region's increase in gonococcal
cases. Portland, in the northwestern part of the state, 110 miles (177
km) north of Eugene, is Oregon's most populous city and is the 2nd
most populous city in the US Pacific Northwest region, after Seattle,
Washington.

In Idaho, Magic Valley, an agricultural region in south-central part
of the state, consists of 8 counties, with popular resorts, e.g., Sun
Valley, for skiing, camping, hunting and fishing
(<http://en.wikipedia.org/wiki/Magic_Valley>). Boise is the capital
and most populous city of the state.

The recent increase in syphilis and gonococcal disease in Oregon was
previously reported to be occurring among men who have sex with men
(MSM), which is similar to the situation in many other jurisdictions
in the US and other countries; see a ProMED-mail post (Syphilis &
gonococcal dis. - USA (04): (OR) rising incidence, MSM, HIV coinfect
20140608.2527642). This article posted by ProMED-mail reported that
"HIV-infected gay men often choose HIV-positive partners to avoid
using condoms, but they still can transmit STDs." The outbreak among
MSM has been characterized by high rates of HIV coinfection, high-risk
sexual behavior, use of drugs such as methamphetamines, use of
Internet chat rooms to meet sex partners
(<http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5510a1.htm>), and more
recently, use of smartphone applications like Grindr, a gay social
networking site.

CMAJ July 8 758-760. New treatments for metastatic melanoma TORONTO Anthony Joshua MBBS(NSW) PhD et al

Paper discussed
YERVOY ( Ipilimumab) Bristol-Myers Squibb given by IV drip once every 3 weeks for 4 doses.Cost: $120,000
ZELBORAF(Vemurafenib)Roche. Orally.960mg every 12 hours. $11,000/month for 6 months.= $66.000.

NOT PAID in ATLANTIC PROVINCES (New Brunswick,Nova Scotia & Prince Edward Island and TERRITORIES.(N.W.Territory, Nunavuk,Yukon)

(Comment: In Canada Geography could determine length of life. Patients can move to a more generous Province. QUEBEC is best. Logically Federal control of Medicine would remove this absurd situation).

11 July 2014

Harvard ProMed: SYPHILIS in SWEDEN






SYPHILIS - SWEDEN: RISING INCIDENCE, DECREASING CONDOM USE
**********************************************************
A ProMED-mail post

ProMED-mail is a program of the
International Society for Infectious Diseases


Date: Thu 10 Jul 2014
Source: The Swedish Wire [edited]



Swedish Radio News said the Scandinavian country saw a sharp uptick in
the number of cases of syphilis last year [2013], while new cases of
chlamydia and gonorrhea are showing signs of slowing down.

The agency reported 275 new cases of syphilis, an increase of 37
percent from 2012; half of which have taken place abroad.

"Changed sexual behavior has contributed to sexually transmitted
diseases becoming common. Studies show that condom use among young
people is quite low with new and casual partners," epidemiologist Inga
Velicko at the agency told Swedish Radio.

[Byline: Johan Nylander]

--
Communicated by:
ProMED-mail from HealthMap Alerts


[The increased incidence of syphilis in Sweden is similar to the
situation in the US and other countries (see prior ProMED-mail posts
below). In many countries, the increased incidence of syphilis is
occurring mainly among men who have sex with men (MSM), and has been
characterized by high rates of human immunodeficiency virus (HIV)
co-infection, high-risk sexual behavior, use of drugs such as
methamphetamines, use of Internet chat rooms to meet sex partners
(), and more
recently, use of smartphone applications like Grindr, a gay social
networking site. The news report above does not give more information
about the epidemiology of the rising incidence of syphilis in Sweden.

However, a Eurosurveillance article in 2008 reported that the spread
of syphilis in Sweden among MSM, particularly in the big cities, has
been a major contributor to an increase in cases in that country
(Velicko I, Arneborn M, Blaxhult A. Syphilis epidemiology in Sweden:
re-emergence since 2000 primarily due to spread among men who have sex
with men. Eurosurveill. 2008;13(50). Available online:
).
Estimated syphilis incidence among Swedish MSM was up to 28 times
higher than in the general Swedish male population. The most affected
age group among males was 25-44 years of age. The majority of
infections in men and women through heterosexual contacts were
acquired abroad, whereas the majority of infections attributed to sex
between men were acquired in Sweden. - Mod.ML

A HealthMap/ProMED-mail map can be accessed at:
.]

10 July 2014

UK DAILY MAIL: PHOTOSYNTHESIS :

Photosynthesis in action: Scientists capture moment plant converts energy

  • Team led by Arizona State University observes photosynthesis in action
  • They were able to take a freeze-frame of plant process that creates oxygen
  • They observed the molecular changes using X-ray flashes at a lab
  • This snapshot lasted just 30 quadrillionths of a second
  • And the research could be used to make artificial leaves, the so-called 'holy grail' of biochemistry

Scientists have announced they are closer than ever to the ‘holy grail’ of biochemistry: artificial photosynthesis.
By observing the first stage of the process in action, they say they’ve got a better understanding of how plans turn carbon dioxide into oxygen.
And ultimately it may be an important step to a future where artificial plants are created that are more efficient than their organic siblings.
Scientists have observed the water splitting process in plants that creates oxygen, known as photosystem II. The cycle, illustrated here, has four steps. The largest change is between steps S1 and S3, so this is the part the scientists 'zoomed in' on to capture their freeze-frame
Scientists have observed the water splitting process in plants that creates oxygen, known as photosystem II. The cycle, illustrated here, has four steps. The largest change is between steps S1 and S3, so this is the part the scientists 'zoomed in' on to capture their freeze-frame

The groundbreaking research published in Nature was carried out by an international team led by Arizona State University (ASU) scientists.

PHOTOSYNTHESIS IN A NUTHSELL

The process through which plants absorb light using chlorophyll to produce chemical energy in the form of oxygen, glucose and more is called photosynthesis.
During the process glucose is used by the plants to breathe or is converted into starch, while oxygen is released as a waste product – in turn giving us the air we need to breathe.
The rate of photosynthesis is altered by differing carbon dioxide levels and light intensity. If either is increased then the process will also increase, up to a limit.
Temperature also plays a part, with a higher temperature increasing the rate.
However if the temperature is too high, beyond 40C, the rate slows down.
Photosynthesis provides most of the energy necessary for life on Earth to exist.
But no way to artificially mimic the process has yet been created, leaving us dependent on plants to survive and thrive.
In the study they were able to observe the first snapshots of photosynthesis in action as it split water into protons, electrons and oxygen.
This is the process that maintains Earth’s oxygen atmosphere and ensures air is made up of the things we need to breathe it and survive.
 
‘This study is the first step towards our ultimate goal of unraveling the secrets of water splitting and obtaining molecular movies of biomolecules,’ said Professor Petra Fromme, professor of chemistry and biochemistry at ASU and leader of the research team.
Photosynthesis is one of the fundamental processes of life on Earth.
The early Earth contained no oxygen and was only converted to the oxygen-rich atmosphere we have today 2.5 billion years ago by the ‘invention’ of the water splitting process that occurs in photosynthesis.
This water splitting process is known as photosystem II (PSII), which produces the oxygen we breathe and ultimately keeps us alive.
Revealing the mechanism of this process is essential for the development of artificial systems that mimic and surpass the efficiency of natural systems.
In the study they were able to observe the first snapshots of photosynthesis in action as it split water into protons, electrons and oxygen. This is the process that maintains Earth¿s oxygen atmosphere and ensures air is made up of the things we need to breathe it and survive
In the study they were able to observe the first snapshots of photosynthesis in action as it split water into protons, electrons and oxygen. This is the process that maintains Earth¿s oxygen atmosphere and ensures air is made up of the things we need to breathe it and survive

The development of an ‘artificial leaf’ is one of the major goals of the ASU Center for Bio-Inspired Solar Fuel Production, which was the main supporter of this study.
Director of the centre Professor Devens Gust explained that they are trying to find a way to turn water into oxygen gas, hydrogen ions and electrons just like plants do.
‘Photosynthetic organisms already know how to do this, and we need to know the details of how photosynthesis carries out the process using abundant manganese and calcium,’ he said.
‘Once the mechanism of photosynthetic water oxidation is understood, chemists can begin to design artificial photosynthetic catalysts that will allow them to produce useful fuels using sunlight.’
The team, led by Professor Fromme, used the world's most powerful X-ray flashlight at the US National Accelerator Laboratory to record still frames of the molecule complex PSII as it splits water into hydrogen and oxygen.
‘This is the very first scene of a molecular movie showing light-driven water splitting in photosystem II, the mechanism which makes all oxygen in the atmosphere,’ said Fromme.
Co-author Professor Henry Chapman from the Deutsches Elektronen-Synchrotron (Desy) added: ‘A deeper understanding of photosynthesis could, for instance, aid the development of better solar cells and might advance the quest for biochemistry's holy grail, artificial photosynthesis.’
The process through which plants absorb light using chlorophyll to produce chemical energy in the form of oxygen, glucose and more is called photosynthesis. Shown is a Cyanobacteria cell, which was an early form of plant life that converted the Earth's early atmosphere into a breathable one
The process through which plants absorb light using chlorophyll to produce chemical energy in the form of oxygen, glucose and more is called photosynthesis. Shown is a Cyanobacteria cell, which was an early form of plant life that converted the Earth's early atmosphere into a breathable one

To observe photosystem II in action, the team grew tiny nano-crystals of the photosystem II complex of bacteria that employ photosynthesis, cyanobacteria called Thermosynechococcus elongatus.
These crystals were illuminated with a visible laser to start the water splitting process, which is otherwise driven by sunlight.
The researchers used double light flashes to trigger the transition and, with the short and intenses X-ray laser flashes, were able to monitor how the molecular structure changed in the process.
This provided just enough time to freeze-frame the water splitting process for 30 quadrillionths of a second.
But that was enough to glean the snapshot of the process in action - and now they’ll be hoping to take the research further and see the rest of the photosynthesis process.

Read more: http://www.dailymail.co.uk/sciencetech/article-2687703/Photosynthesis-action-Scientists-capture-moment-plant-converts-energy-help-create-man-plants.html#ixzz376oxH09n
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05 July 2014

SWITZERLAND:: VASCULAR DYSFUNCTION in CHILDREN CONCEIVED by Assisted reproductive technologies.


Review article: Medical intelligence | Published 25 June 2014, doi:10.4414/smw.2014.13973
Cite this as: Swiss Med Wkly. 2014;144:w13973

Vascular dysfunction in children conceived by assisted reproductive technologies: underlying mechanisms and future implications

Stefano F. Rimoldia, Claudio Sartorib, Emrush Rexhaja, David Cernya, Robert von Arxa, Rodrigo Soriaa, Marc Germondc, Yves Allemanna, Urs Scherrera,d
a Department of Cardiology and Clinical Research, Inselspital, University Hospital, Bern, Switzerland
b Botnar Centre for Extreme Medicine, Department of Internal Medicine, University Hospital, Lausanne
c Centre de Procréation Médicalement Assistée, Lausanne, Switzerland
d Facultad de Ciencias, Departamento de Biología, Universidad de Tarapacá, Arica, Chile

Summary

Epidemiological studies in humans have demonstrated a relationship between pathological events during fetal development and increased cardiovascular risk later in life and have led to the so called “Fetal programming of cardiovascular disease hypothesis”. The recent observation of generalised vascular dysfunction in young apparently healthy children conceived by assisted reproductive technologies (ART) provides a novel and potentially very important example of this hypothesis. This review summarises recent data in ART children demonstrating premature subclinical atherosclerosis in the systemic circulation and pulmonary vascular dysfunction predisposing to exaggerated hypoxia-induced pulmonary hypertension. These problems appear to be related to the ART procedure per se. Studies in ART mice demonstrating premature vascular aging and arterial hypertension further demonstrate the potential of ART to increase cardiovascular risk and have allowed to unravel epigenetic alterations of the eNOS gene as an underpinning mechanism. The roughly 25% shortening of the life span in ART mice challenged with a western style high-fat-diet demonstrates the potential importance of these alterations for the long-term outcome. Given the young age of the ART population, data on cardiovascular endpoints will not be available before 20 to 30 years from now. However, already now cohort studies of the ART population are needed to early detect cardiovascular alterations with the aim to prevent or at least optimally treat cardiovascular complications. Finally, a debate needs to be engaged on the future of ART and the consequences of its exponential growth for public health.
Key words: in vitro fertilization; endothelium; epigenetic; eNOS; arterial hypertension; pulmonary hypertension; preeclampsia